Mazzuoli GF, Passeri M, Gennari C, Minisola S, Antonelli R, Valtorta C, Palummeri E, Cervellin GF, Gonneli S, Francini G (1986) Effects of salmon calcitonin in postmenopausal osteoporosis: a controlled double-blind clinical study. Metabolism 33:295–303Īloia JF, Vaswani A, Kapoor A, Yeh JK, Cohn SH (1985) Treatment of osteoporosis with calcitonin, with and without growth hormone. Gruber HE, Ivey JL, Baylink DJ, Matthews M, Nelp WB, Sisom K, Chestnut, CH (1984) Long-term calcitonin therapy in postmenopausal osteoporosis. In: Pecile A (ed) Calcitonin 1980: chemistry, physiology, pharmacology and clinical aspects. Curr Ther Res 22:556–572Īgrawal RS, Wallach S, Cohn SH, Tessier M, Verch R, Hussain M, Zanzi I (1981) Calcitonin treatment of osteoporosis.
Wallach S, Cohn SH, Atkins HL, Ellis KJ, Kohberger R, Aloia JF, Zanzi I (1977) Effect of salmon calcitonin on skeletal mass in osteoporosis. Evaluation of efficacy by principal components analysis. Milhaud G, Talbot JN, Coutris G (1975) Calcitonin treatment of postmenopausal osteoporosis. The present study suggests a prolonged beneficial effect of the combination of high doses of vitamin D with rather moderate (<150 MRC U/week) doses of calcitonin in postmenopausal osteoporosis.Ĭohn SH, Dombrowski CS, Hauser W, Klopper J, Atkins HL (1971) Effects of porcine calcitonin on calcium metabolism in osteoporosis. Previous reports suggest that calcitonin alone or with small doses of vitamin D increased bone mass for about 2 years. Because single photon densitometry reflects mostly cortical bone, the data suggest that the combination of vitamin D and calcitonin increases trabecular bone mass and prevents the fall of cortical bone mass in osteoporosis. Iliac crest bone biopsies obtained at the initiation and conclusion of the study showed a 43% increment in trabecular bone volume ( P=0.0003), without changes of the normal osteoid thickness, surface, and volume. Single photon bone densitometry of the radius did not change. The fracture rate in 11 patients with vertebral compression fracture was 240/1,000 patient years, threefold lower than the reported 834 fractures for untreated patients of similar age. No side effects, hypercalcemia, or hypercalciuria occurred.
Thirteen women with postmenopausal osteoporosis received this treatment for 2–6 years (mean 3.5 years). We tested the hypothesis that chronic treatment with high doses of vitamin D (150,000 U/week), moderate doses of salmon calcitonin (120 MRC U/week), and adequate Ca supplementation (1 g/day) could be beneficial in osteoporosis. Calcitonin inhibits the function of osteoclasts, reducing bone resorption, thus, the combination of vitamin D and calcitonin could result in a positive bone balance. Vitamin D has complex effects in bone: it stimulates matrix formation and bone maturation but also enhances osteoclastic activity and may influence differentiation of bone cell precursors.
0 kommentar(er)
